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Publications

Service and Collaboration Research

  • Ou Yang CW, Hung SI, Juo CG, Lin YP, Fang WH, Lu IH, Chen ST, Chen YT. Human leukocyte antigen-B* 1502-bound peptides: Implication on the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immun, in press, 2007.

  • Liu CM, Liu YL, Fann CS, Yang WC, Wu JY, Hung SI, Chen WJ, Chueh CM, Liu WM, Liu CC, Hsieh MH, Hwang TJ, Faraone SV, Tsuang MT, Hwu HG. No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families. Schizophr Res. 93:391-8, 2007.

  • Liu CM, Liu YL, Fann CS, Chen WJ, Yang WC, Ouyang WC, Chen CY, Jou YS, Hsieh MH, Liu SK, Hwang TJ, Faraone SV, Tsuang MT, Hwu HG. Association evidence of schizophrenia with distal genomic region of NOTCH4 in Taiwanese families. Genes Brain Behav 2006 Oct 19.

  • Hung SI, Chung WH Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fan WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genom 16:297-306, 2006.
  • Niu DM, Hwang BT, Hwang HW, Wang NH, Wu, JY, Lee PC, Chien JC, Shieh RC, Chen YT. A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect. J Med.Gene, 43:817-21, 2006.

  • Lin WH, Chuang LM, Chen CH, Yeh JI, Hsieh PS, Cheng CH, Chen YT.Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in Taiwanese population. Diabetologia, 49(6):1214-21,2006.

  • Li LH, Ho SF, Chen CH, Wei CY, Wong WC, Li LY, Hung SI, Chung WH, Pan WH, Lee MT, Tsai FJ, Chang CF, Wu JY, Chen YT.Long contiguous stretches of homozygosity in the Human Genome, Hum Mutat, 27(11):1115-21, 2006.

  • YF Liu, WM Chen, YF Lin ,RC Yang , MW Lin, LH Li, YH Chang , YS Jou, PY Lin , JS Su SF Huang, KJ Hsiao , CSJ Fann, HW Hwang, YT Chen, SF Tsai. Mutations in the Type II Collagen Gene and Inherited Form of Osteonecrosis of the Femoral Head.New Engl J Med 352:2294-301, 2005.

  • WL Hwu1, CF Yang, CSJ Fann, CL Chen, TF Tsai, YH Chien, SC Chiang, CH Chen, SI Hung, JY Wu, YT Chen.Mapping of psoriasis to 17q terminus. J Med Genet 42: 152-8, 2005.

  • HY Yuan, JJ Chen, MT Michel Lee, YF Chen, MJ Charng, MJ LU, CR Hung, CY Wei, CH Chen, JY Wu, YT Chen.A novel functional VKORC1 promoter polymorphysm is associated with inter-vidual and inter-ethnic differences in wafarin sensitivity. Hum Mol Genet 14:1745-51, 2005.

  • SI Hung, WH Chung, LB Liou, CC Chu, M Lin, HP Huang, YL Lin, JL Lan, LC Yang, HS Hong, MJ Chen, PC Lai, CH Chen, CSJ Fann, JY Wu, YT Chen.HLA*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci 102:4134-9, 2005.

  • Hung SI et al. HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine. Invited review Personalized Medicine, 2005.

  • WH Chung, SI Hung, HS Hong, MS Hsih, LC Yang, HC Ho, JY Wu, YT.Chen.Medical genetics: a marker for Stevens-Johnson syndrome. Nature 428: 486, 2004

  • WM Chen, YF Liu, MW Lin, IC Chen, PY Lin, GL Lin, YS Jou, YT Lin, CSJ Fann, JY Wu, KJ Hsiao & SF Tsai.Report of Pedigrees of Autosomal Dominant Avascular Necrosis of Femoral Head and Linkage to Chromosome 12q13. Am J Hum Genet 75:310-7, 2004.

  • HW Hwang, DM Niu, BT Hwang, JJ Chen, YJ Lin, RC Shieh, MT Lee, SI Hung, JY Wu, YT Chen. R1193Q of SCN5A, a Brugada and long QT mutation, is a common polymorphism in Han Chinese.J Med Genet 42:e7, 2004.

R & D Activities

  • Pan WH, Fann CJS, Wu JY, Hung YT, Ho MS, Ta TH, Chen YJ, Liao CJ, Yang ML, Cheng ATA, Chen YT. Han Chinese Cell and Genome bank in Taiwan: purpose, design and ethical considerations. Hum Hered 61:27-30, 2006.
  • Yang HC, Liang YJ, Huang MC, Li LH, Lin CH, Wu JY, Chen YT, Fann CS. A genome-wide study of preferential amplification/ hybridization in microarray-based pooled DNA experiments. Nucleic Acids Res. 34:e106, 2006.
  • Yang HC, Lin CH, Hsu CL, Hung SI, Wu JY, Pan WH, Chen YT, Fann CS. A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. J Biomed Sci. 13:489-98, 2006.
  • Yang HC, Lin CH, Hung SI, Fann CS. A comparison of individual genotyping and pooled DNA analysis for polymorphism validation prior to large-scale genetic studies. Ann Hum Genet 70:350-9,2006
  • Yang HC,Pan CC,Lin CY,Fann CS. PDA: pooled DNA analyzer PDA: pooled DNA analyzer. BMC Bioinformatics, 28;7:233, 2006.
  • Yang HC, Pan CC, Lu Richard CY, Fann CS. New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification. Genetics 169:399-410, 2005.

Books

  • Hung SI, Chung WH and Chen YT: Genetics of severe drug hypersensitivity reactions in Han Chinese. In: Pichler WJ (ed), Drug Hypersensitity, S. Karger AG, 2007.

Patents

  • Gene for psoriasis, 2004.
  • Genetic markers for Wafarin sensitivity,2004.
  • Genetic markers for Stevens-Johnson syndrome, 2003.

國家基因醫藥臨床中心 台北市南港區研究院路二段128號 生物醫學科學研究所100B
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